[The stress-protector properties of new analogs of mediator amino acids]

Stress-protective effect of phosphonglycerid and acyl analogs of neurotransmitter amino acids, which displayed nootropic activity was obtained. These compounds exerted positive influence on behavioral failure and morphological statement after 18-h immobilization. Dilithium-N-acetyl-L-aspartic acid (AKF-94) and di(3-dimethoxyphosphorylpropyl) ester of N-acetyl-DL-aspartic acid (PIR-87-6-0) displayed the most expressive activity. Previously activating influence of these compounds at excitatory amino acid transmission had been shown. We supposed participation of this way in stress-protective effect of new compounds.