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[Evaluation of conjunctival epithelial damage in dry eye]
T Suzuki1, N Yokoi, Y Takehisa
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Nippon Ganka Gakkai Zasshi
|January 1, 1997
Summary
Sulphorhodamine B effectively detects conjunctival damage in dry eye patients, correlating with corneal damage. Sjögren
Area of Science:
- Ophthalmology
- Cell Biology
Context:
- Dry eye disease affects millions globally, impacting ocular surface health.
- Accurate assessment of ocular surface damage is crucial for effective dry eye management.
Purpose:
- To evaluate conjunctival epithelial damage in dry eye patients using sulphorhodamine B.
- To investigate the correlation between sulphorhodamine B and fluorescein staining.
- To compare conjunctival damage severity between Sjögren's syndrome and non-Sjögren's dry eye patients.
Summary:
- Sulphorhodamine B, a sensitive dye, was used to assess conjunctival epithelial damage in 50 dry eye patients (99 eyes).
- A high correlation was observed between sulphorhodamine B staining of conjunctival damage and fluorescein staining of corneal damage.
- Conjunctival damage was generally more severe in patients with Sjögren's syndrome compared to those without.
Impact:
- Sulphorhodamine B offers a valuable tool for quantifying conjunctival epithelial damage in dry eye.
- Findings highlight the utility of sulphorhodamine B in assessing ocular surface integrity in dry eye disease.
- This research aids in understanding disease severity and progression in different dry eye subtypes.