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Long-term survival in patients with advanced immunodeficiency
G Chêne1, P J Easterbrook, E Juszczak
1Medical Statistics Unit, London School of Hygiene and Tropical Medicine, Chelsea and Wistminster Hospital, London, UK.
AIDS (London, England)
|February 1, 1997
Summary
Prognostic factors like age, hemoglobin, and CD4 cell decline rate predict survival in advanced HIV. A developed score aids in predicting patient outcomes with immunodeficiency.
Area of Science:
- Immunology
- Clinical Medicine
- Epidemiology
Background:
- Advanced human immunodeficiency virus (HIV) infection is characterized by severe immunodeficiency.
- Predicting survival in these patients is crucial for clinical management.
Purpose of the Study:
- To identify prognostic factors associated with survival time in HIV-infected patients with advanced immunodeficiency (CD4 count ≤ 50 cells/µL).
Main Methods:
- Prospective cohort study of 1284 HIV-infected patients with serial CD4 counts.
- Survival was analyzed from the point of CD4 count falling to ≤ 50 cells/µL.
Main Results:
- Median survival was 17.1 months.
- Increased risk of death was associated with older age, lower hemoglobin levels, and faster CD4 cell decline.
- Longer duration of acquired immunodeficiency syndrome (AIDS) diagnosis prior to reaching a CD4 count ≤ 50 cells/µL also increased mortality risk.
Conclusions:
- Routinely available clinical and laboratory data can be used to develop a prognostic score.
- This score can effectively predict survival outcomes for HIV-infected patients with advanced immunodeficiency.