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Updated: Aug 17, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
[Conjugal psoriasis and its relation to histocompatibility antigens. A family study]
Abstract:
The higher risk of the occurrence of psoriasis vulgaris in the progeny of conjugal psoriasis marriages was repeatedly reported. In this paper a family, where the parents and both the children are suffering from psoriasis is described. The disease occurs also in some of the blood relatives of the father and mother. The occurrence of the disease and the segregation of the HLA antigens was followed in the kinship. It seems that a genetic factor linked to the HLA system influences the developement of psoriasis vulgaris.
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01:43Sex-linked Disorders
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01:11Genome-wide Association Studies-GWAS
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...