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Development of an implantable ventricular assist system
M P Macris1, S M Parnis, O H Frazier
1Cullen Cardiovascular Research Laboratories, Department of Cardiovascular Surgical Research, Texas Heart Institute, Houston 77030, USA.
The Annals of Thoracic Surgery
|February 1, 1997
Summary
The Jarvik 2000 ventricular assist system shows promise for long-term patient support. This implantable blood pump demonstrated feasibility in animal studies with no significant complications.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
- Medical Technology
Background:
- The Jarvik 2000 is an intraventricular axial-flow blood pump designed for implantation.
- It utilizes a transcutaneous energy transfer system and internal batteries for power.
Purpose of the Study:
- To describe the development progress of the Jarvik 2000 ventricular assist system.
- To evaluate the feasibility and safety of the device in animal models.
Main Methods:
- The system features a compact (25 cm3, 90 g) blood pump with internal electronics.
- Power is supplied by internal and external polymer lithium ion batteries.
- A brushless direct-current motor with redundant coil design ensures operational continuity.
Main Results:
- Seven calves were supported for an average of 107 days (40-162 days).
- No physiological complications were observed; renal and hepatic functions remained normal.
- Mean plasma free hemoglobin levels were low (mean, 6.3 mg/dL), and no device-related organ damage was found.
Conclusions:
- The Jarvik 2000 ventricular assist system is feasible in animal subjects.
- The device shows potential for long-term circulatory support in patients.