Related Experiment Video
Updated: Jul 27, 2026
11:59
Competitive Genomic Screens of Barcoded Yeast Libraries
Published on: August 11, 2011
A novel rapid throughput phototolerance screen in mice
M A Shapiro1, J C Sesnie, E T Joannides
1Department of Infectious Diseases, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, Michigan 48105, USA.
Journal of Pharmacological and Toxicological Methods
|December 1, 1996
Summary
A new in vivo mouse phototolerance screen offers a rapid method for early drug development. This assay helps identify and prioritize drug candidates based on their light sensitivity, improving lead compound selection.
Area of Science:
- Pharmacology
- Drug Development
- Toxicology
Background:
- Phototolerance screening is crucial for early drug development.
- A need exists for rapid, high-throughput methods in preclinical studies.
- Assessing compound light sensitivity aids in lead compound selection.
Purpose of the Study:
- To establish a simple, rapid, high-throughput in vivo mouse phototolerance screen.
- To validate the screen's utility in early drug development.
- To report phototolerance data for reference drugs using the developed screen.
Main Methods:
- Development of an in vivo phototolerance assay in mice.
- Application of the screen to assess light sensitivity of compounds.
- Data collection and analysis of phototolerance in response to light exposure.
Main Results:
- Successful establishment of a functional mouse phototolerance screen.
- Demonstration of the screen's ability to differentiate compound phototolerance.
- Generation of phototolerance data for standard reference drugs.
Conclusions:
- The developed in vivo mouse phototolerance screen is a valuable tool for early drug discovery.
- This assay enables efficient prioritization of potential drug candidates.
- The screen provides reliable phototolerance data for preclinical assessment.
