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Surveillance bronchoscopy in lung transplant recipients
D S Kukafka1, G M O'Brien, S Furukawa
1Department of Medicine, Temple University School of Medicine, Philadelphia.
Chest
|February 1, 1997
Summary
Most lung transplant centers use surveillance bronchoscopic lung biopsy (SBLB) regularly. However, significant variation exists in its application and interpretation, necessitating further research to clarify its impact on patient outcomes.
Area of Science:
- Pulmonology
- Transplant Surgery
- Medical Diagnostics
Background:
- Surveillance bronchoscopic lung biopsy (SBLB) is a diagnostic tool used in lung transplantation.
- There is a need to understand current practices and consensus among transplant centers regarding SBLB.
Purpose of the Study:
- To determine the level of consensus among active lung transplant centers on the use and interpretation of surveillance bronchoscopic lung biopsy (SBLB).
Main Methods:
- A prospective, standardized questionnaire was distributed via mail and telephone to North American and international lung transplant programs.
- Data analysis included responses from 57 active programs, representing 63% of surveyed centers.
Main Results:
- 68% of active centers perform SBLBs, with most using them within the first month post-transplant and continuing regularly.
- While 86% believe SBLB impacts patient management, there is variability in biopsy techniques and treatment thresholds for rejection.
- Complications associated with SBLB were reported to be minimal (<5%).
Conclusions:
- Most lung transplant centers utilize SBLB routinely, but consensus on its optimal use, interpretation, and impact on patient outcomes is lacking.
- A randomized, multicentered trial or registry is recommended to definitively assess the effect of SBLB on lung transplant recipient morbidity and mortality.