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Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease
A Bierhaus1, E Ritz, P P Nawroth
1Department of Internal Medicine, University of Heidelberg, Germany.
Abstract:
Formation and deposition of advanced glycation end-products (AGEs) has been linked to late diabetic complications. Interactions of AGEs are at least partly mediated by binding of AGEs to their cellular surface receptor RAGE. This review summarizes the immunohistological data obtained for RAGE distribution in vessel segments of diabetic and non-diabetic patients with peripheral occlusive vascular disease and in kidneys of patients with diabetic nephropathy, and inflammatory and non-inflammatory renal disease. It is demonstrated that increased RAGE expression is not restricted to diabetes mellitus but contributes to a range of vascular and renal disorders.
Insights
Increased receptor for advanced glycation end-products (RAGE) expression is linked to diabetic complications. This review shows elevated RAGE in various vascular and renal disorders, not just diabetes.
Area of Science:
- Biomedical Science
- Pathology
- Molecular Biology
Background:
- Advanced glycation end-products (AGEs) contribute to diabetic complications.
- AGEs interact with cellular surface receptor for advanced glycation end-products (RAGE).
- RAGE expression is implicated in various pathological processes.
Purpose of the Study:
- To review immunohistological data on RAGE distribution.
- To investigate RAGE expression in diabetic and non-diabetic vascular and renal diseases.
- To determine if increased RAGE expression is specific to diabetes mellitus.
Main Methods:
- Review of immunohistological data.
- Analysis of RAGE distribution in vessel segments.
- Examination of RAGE expression in kidney tissues.
Main Results:
- Increased RAGE expression was observed in diabetic and non-diabetic patients.
- RAGE distribution was analyzed in peripheral occlusive vascular disease.
- Elevated RAGE expression was found in diabetic nephropathy and other renal diseases.
Conclusions:
- Increased RAGE expression is not exclusive to diabetes mellitus.
- RAGE contributes to the pathogenesis of diverse vascular and renal disorders.
- RAGE is a potential therapeutic target for multiple diseases.