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Pulmonary hemosiderosis with hypersensitivity to buckwheat
1Department of Pediatrics, Gifu University School of Medicine, Japan.
Summary
This study found a patient with pulmonary hemosiderosis linked to buckwheat protein hypersensitivity, not IgE-mediated. This suggests non-immediate hypersensitivity mechanisms may be involved in buckwheat-related lung disease.
Area of Science:
- Immunology
- Gastroenterology
- Pulmonology
Background:
- Buckwheat allergy is typically IgE-mediated.
- Pulmonary hemosiderosis can be linked to cow milk sensitivity.
- This case presents pulmonary hemosiderosis associated with buckwheat protein without elevated IgE.
Observation:
- A patient with pulmonary hemosiderosis and buckwheat sensitivity was studied.
- Standard allergy tests (RAST, skin prick) for buckwheat were negative.
- Cellular immune response (mononuclear cells) to buckwheat was observed.
Findings:
- Skin patch testing revealed a positive reaction to buckwheat protein.
- Peripheral blood mononuclear cells showed proliferative responses to buckwheat.
- The patient exhibited non-immediate hypersensitivity to buckwheat protein.
Implications:
- Suggests non-IgE mediated hypersensitivity in buckwheat-induced pulmonary hemosiderosis.
- Highlights the importance of considering delayed hypersensitivity mechanisms.
- Broadens understanding of food protein-induced lung diseases.