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[Acute water intoxication caused by intranasal desmopression--Minirin]
1Sønderborg Sygehus, anaestesiologisk afdeling.
Ugeskrift for Laeger
|January 13, 1997
Summary
Desmopressin treats nocturnal enuresis but can cause water intoxication with hyponatremia and seizures. Parents should monitor for symptoms like nausea or cramps and consult a doctor if they appear.
Area of Science:
- Pediatric Nephrology
- Clinical Pharmacology
Background:
- Desmopressin is a common treatment for nocturnal enuresis.
- Intranasal desmopressin carries known risks including water intoxication, hyponatremia, and seizures.
Observation:
- A case study details a healthy child experiencing water intoxication with severe hyponatremia and a grand mal seizure during desmopressin treatment for enuresis.
- Symptoms of abdominal cramps and nausea preceded the seizure, with brain CT suggesting increased intracranial pressure.
Findings:
- The child fully recovered after medical intervention.
- This case highlights a severe adverse event associated with desmopressin use in pediatric enuresis treatment.
Implications:
- Emphasizes the critical need for comprehensive patient and parent education regarding desmopressin administration and potential risks.
- Recommends immediate discontinuation of desmopressin and medical consultation for symptoms like abdominal cramps, nausea, or headache to monitor serum sodium levels.
- Suggests temporary desmopressin withdrawal during acute illnesses that may affect water balance.