Comorbidity of migraine and psychiatric disorders

This article reviews the evidence for comorbidity of migraine with psychiatric disorders, particularly the affective and anxiety disorders. Studies of the association between migraine and depression in both clinical and community studies have provided consistent evidence regarding a substantial degree of comorbidity between these disorders, regardless of the index disorder for which the subject sought treatment in the clinical settings. Methodologic issues, possible mechanisms, and implications of comorbidity for clinical practice and future research are discussed.