Related Experiment Videos
Thrombus in right atrium in two infants successfully treated with tissue plasminogen activator
E Martínez-Tallo1, F Campo, M Delgado
1Division of Pediatric Intensive Care and Pediatric Cardiology, Infanta Cristina University Hospital, Badajoz, Spain.
Abstract:
The widespread use of central venous catheters in children has increased thrombotic complications that warrant thrombolytic therapy. We report the cases of two infants, aged four and two months, with a mobile thrombus in the right atrium treated with recombinant tissue-plasminogen-activator (rt-PA) infused by a central venous catheter. Clot dissolution was obtained in both patients in eight and 44 hours, respectively. One patient presented mild respiratory distress probably from a pulmonary microembolism that disappeared in a few days. Both had minor bleeding from venipuncture sites, but no major hemorrhage.