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Related Experiment Videos

AP-1 function and regulation

M Karin1, Z g Liu, E Zandi

  • 1Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA. palford@ucsd.edu

Current Opinion in Cell Biology
|April 1, 1997
PubMed
Summary
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Activating protein-1 (AP-1) transcription factors, composed of Jun, Fos, and ATF subunits, regulate distinct biological functions. Recent studies using gene-knockout models are clarifying their roles in cell proliferation and survival.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Activating protein-1 (AP-1) is a collective term for dimeric transcription factors (Jun, Fos, ATF subunits).
  • AP-1 factors bind to specific DNA sequences, regulating gene expression.
  • The precise physiological functions of diverse AP-1 factors have been historically challenging to elucidate.

Purpose of the Study:

  • To clarify the distinct biological functions of different AP-1 factors.
  • To elucidate the mechanisms regulating AP-1 activity.
  • To understand the role of AP-1 in cellular processes like proliferation and survival.

Main Methods:

  • Analysis of gene-knockout mice lacking specific AP-1 components.
  • Studies on cell lines deficient in particular AP-1 factors.

Related Experiment Videos

  • Investigation of signaling pathways and protein interactions affecting AP-1 activity.

    • Main Results:

    • Evidence suggests distinct AP-1 factors regulate different target genes, mediating unique biological functions.
    • The role of AP-1 in cell proliferation and survival is becoming clearer.
    • Significant progress has been made in understanding AP-1 regulation via heterodimerization, protein kinases, and coactivators.

    Conclusions:

    • Recent genetic studies are reversing the trend of decreased understanding of AP-1 physiological functions.
    • AP-1 factors play crucial, distinct roles in cellular processes.
    • Complex regulatory mechanisms involving protein interactions and signaling pathways govern AP-1 activity.