Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoisolation: at a turning point

R P Lanza1, W L Chick

  • 1BioHybrid Technologies, Shrewsbury, MA 01545, USA. rtla@aol.com

Immunology Today
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Encapsulation technologies.

Tissue engineering·2009
Same author

Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer.

Cloning·2005
Same author

Nobel laureates' letter to President Bush.

The Washington post·2002
Same author

Cloned cattle can be healthy and normal.

Science (New York, N.Y.)·2001
Same author

The ethical reasons for stem cell research.

Science (New York, N.Y.)·2001
Same author

The ethical validity of using nuclear transfer in human transplantation.

JAMA·2001
Same journal

Foreword.

Immunology today·2020
Same journal

The origin and significance of anti-DNA antibodies.

Immunology today·2014
Same journal

Mutations of class II MHC molecules.

Immunology today·2014
Same journal

Antigen processing at the molecular level.

Immunology today·2014
Same journal

Phenotypically and functionally distinct T-cell subsets in anti-tumor responses.

Immunology today·2014
Same journal

Are MHC class II-restricted cytotoxic T lymphocytes important?

Immunology today·2014
See all related articles

Immunoisolation systems use selectively permeable membranes to shield transplanted cells from immune rejection. This technology allows nutrient exchange while blocking immune cells and antibodies, crucial for successful transplantation.

Area of Science:

  • Biomedical Engineering
  • Transplantation Immunology
  • Regenerative Medicine

Background:

  • Transplant rejection is a major barrier to cell-based therapies.
  • Host immune responses target and destroy transplanted cells.
  • Existing immunosuppressive strategies have significant side effects.

Purpose of the Study:

  • To review the principles and applications of immunoisolation systems.
  • To discuss the design and function of selectively permeable membranes for cell encapsulation.
  • To highlight the potential of immunoisolation in overcoming transplant rejection.

Main Methods:

  • Review of scientific literature on immunoisolation technologies.
  • Analysis of membrane properties and their role in selective permeability.

Related Experiment Videos

  • Discussion of various immunoisolation device designs.

    • Main Results:

    • Immunoisolation membranes effectively separate transplanted cells from host immune effectors.
    • Successful exchange of essential low-molecular-weight substances (nutrients, oxygen) is demonstrated.
    • Exclusion of immune cells, antibodies, and other rejection mediators is confirmed.

    Conclusions:

    • Immunoisolation offers a promising strategy to prevent immune rejection of transplanted cells.
    • This technology has broad implications for various cell therapies, including diabetes and neurodegenerative diseases.
    • Further development of immunoisolation systems is critical for clinical translation.