Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Underlying mechanisms at the bone-surface interface during regeneration

Z Schwartz1, K Kieswetter, D D Dean

  • 1Department of Periodontics, Hebrew University Hadassah Faculty of Dental Medicine, Jerusalem, Israel. MESSIER@UTHSCSA.edu

Journal of Periodontal Research
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of Aging Oral Health on Long COVID-19.

Journal of dental research·2025
Same author

Strategies for Improving Impaired Osseointegration in Compromised Animal Models.

Journal of dental research·2024
Same author

Human Bone Marrow Stromal Cell Exosomes Ameliorate Periodontitis.

Journal of dental research·2022
Same author

Regulation of inflammatory and catabolic responses to IL-1β in rat articular chondrocytes by microRNAs miR-122 and miR-451.

Osteoarthritis and cartilage·2020
Same author

Imaging analysis of the interface between osteoblasts and microrough surfaces of laser-sintered titanium alloy constructs.

Journal of microscopy·2017
Same author

Craniosynostosis and Resynostosis: Models, Imaging, and Dental Implications.

Journal of dental research·2016
Same journal

Shifting Concepts in Esthetic-Zone Implant Therapy: Reflections From a 15-Year Institutional Registry.

Journal of periodontal research·2026
Same journal

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling.

Journal of periodontal research·2026
Same journal

Digital Implant Dentistry: The Past, the Present, the Future.

Journal of periodontal research·2026
Same journal

The Journey of Oral Hygiene: The Past, the Present, the Future.

Journal of periodontal research·2026
Same journal

The Tunneled Coronally Advanced Flap (TCAF) for Root Coverage Procedures: Rationale, Indications, and a Novel Papilla-Based Decision Tree.

Journal of periodontal research·2026
Same journal

Viruses, Periodontitis, and Systemic Diseases.

Journal of periodontal research·2026
See all related articles

Surface characteristics like roughness and chemistry significantly influence cell response, impacting bone regeneration around implants. Optimizing these surface properties is key for successful tissue healing and implant integration.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Implantology

Background:

  • Regenerative therapy aims to maximize the natural potential for periodontal ligament and bone regeneration.
  • Successful regeneration requires addressing factors like inflammation, mechanical stability, space maintenance, tissue isolation, and surface characteristics.

Purpose of the Study:

  • To review how surface characteristics (chemistry and roughness) influence cell response and local factor production.
  • To evaluate the impact of surface materials and titanium roughness on cell behavior in vitro.

Main Methods:

  • Costochondral chondrocytes cultured on sputter-coated plastic dishes with different materials to assess surface chemistry effects.
  • Osteoblast-like cells cultured on titanium surfaces with varying roughness to examine proliferation, differentiation, and matrix production.

Related Experiment Videos

  • Analysis of cytokine and growth factor production (PGE2, TGF-beta) in relation to surface roughness.

    • Main Results:

    • Surface materials differentially affect cell metabolism and phenotypic expression in vitro.
    • Titanium surface roughness influences osteoblast proliferation, differentiation, matrix production, and cytokine/growth factor release.
    • Cell response (proliferation, differentiation markers, matrix production) is not altered on used vs. virgin surfaces, suggesting potential for implant re-use.

    Conclusions:

    • Surface characteristics, particularly roughness, play a crucial role in directing tissue healing and implant success.
    • Osteoblast behavior and local factor production are modulated by implant surface properties.
    • Further research into cleaning procedures for rougher titanium surfaces is warranted for potential implant re-use.