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Targeted gene disruption shows that knobs enable malaria-infected red cells to cytoadhere under physiological shear

B S Crabb1, B M Cooke, J C Reeder

  • 1The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.

Cell
|April 18, 1997
PubMed
Summary

Knob structures on Plasmodium falciparum-infected erythrocytes are essential for their adherence to blood vessels. Disrupting the knob-associated histidine-rich protein (KAHRP) gene prevents knob formation and alters cell adhesion dynamics.

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