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Lactoferrin in tears in contact lens wearers
M J Velasco Cabrera1, J García Sánchez, F J Bermúdez Rodríguez
1Department of Optics, Science Faculty, University of Granada, Spain.
Summary
Contact lens wear can decrease lactoferrin levels in tears, particularly in individuals developing giant papillary conjunctivitis. This study measured lactoferrin in healthy subjects before and after contact lens fitting.
Area of Science:
- Ophthalmology
- Immunology
- Biochemistry
Background:
- Contact lens wear is common, but can lead to ocular complications.
- Giant papillary conjunctivitis (GPC) is an inflammatory condition associated with contact lens wear.
- Lactoferrin is an important protein in tear fluid with antimicrobial and anti-inflammatory properties.
Purpose of the Study:
- To investigate lactoferrin concentration in healthy subjects before and after contact lens wear.
- To compare lactoferrin levels in successful contact lens wearers versus those who develop GPC.
Main Methods:
- Tear stimulation using Allyl sulphide.
- Quantification of lactoferrin concentration via radial immuno-diffusion technique.
- Measurements taken from 126 healthy subjects before and 9 months after contact lens fitting.
Main Results:
- A significant reduction in tear lactoferrin levels was observed in patients who developed GPC.
- Lactoferrin levels in successful contact lens wearers were also assessed for comparison.
Conclusions:
- Contact lens wear may be associated with decreased lactoferrin levels in the tear film.
- Reduced lactoferrin may play a role in the pathogenesis of giant papillary conjunctivitis.