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Structural correlates of cognition in dementia: quantification and assessment of synapse change
S T DeKosky1, S W Scheff, S D Styren
1Department of Psychiatry, Western Psychiatric Institute & Clinic, Pittsburgh, PA 15261, USA. dekosky@vms.cis.pitt.edu
Abstract:
Dementia results from a combination of structural and neurochemical pathologies. The most reliable index of cognition in both postmortem and biopsied AD brain is synapse loss.