Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Postnatal maturation of rat hypothalamoneurohypophysial neurons: evidence for a developmental decrease in calcium

H Widmer1, H Amerdeil, P Fontanaud

  • 1Centre National de la Recherche Scientifique Unité Propre de Recherche 9055, Montpellier, France.

Journal of Neurophysiology
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synaptic communication mediates the assembly of a self-organizing circuit that controls reproduction.

Science advances·2021
Same author

[Lateral approach to the knee combined with an osteotomy of the tibial tuberosity. Its use for total knee replacement].

Operative Orthopadie und Traumatologie·2016
Same author

Combining Cadherin Expression with Molecular Markers Discriminates Invasiveness in Growth Hormone and Prolactin Pituitary Adenomas.

Journal of neuroendocrinology·2015
Same author

Anterior pituitary cell networks.

Frontiers in neuroendocrinology·2012
Same author

BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.

Diabetologia·2010
Same author

Investigating and modelling pituitary endocrine network function.

Journal of neuroendocrinology·2010
Same journal

Comprehensive Analysis of Auditory Nerve Fiber Responses using Fiber-Specific Modeling.

Journal of neurophysiology·2026
Same journal

HCN channels modulate the medium afterhyperpolarization and adjust the firing gain of fast alpha motoneurons in mice.

Journal of neurophysiology·2026
Same journal

Targeting intracranial electrical stimulation to network regions defined within individuals causes network-level effects.

Journal of neurophysiology·2026
Same journal

When "Noise" Isn't Simply Noise: Deterministic Postural Drive During Noisy Galvanic Vestibular Stimulation (nGVS).

Journal of neurophysiology·2026
Same journal

Abrupt Scene Onsets and Gradually Emerging Scene Information Produce Distinct EEG Decoding Dynamics.

Journal of neurophysiology·2026
Same journal

From discovery to translation: charting a course for the <i>Journal of Neurophysiology</i>.

Journal of neurophysiology·2026
See all related articles

During postnatal development, neurosecretory cells in rats show shorter action potentials due to increased potassium currents and decreased calcium current contribution. This developmental change reduces calcium influx into cells.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Electrophysiology

Background:

  • Neurosecretory cells in the rat supraoptic nucleus undergo significant electrophysiological changes during the first three postnatal weeks.
  • These developmental changes are critical for the establishment of neuroendocrine functions.

Purpose of the Study:

  • To investigate the developmental alterations in action potential properties and voltage-gated currents in rat supraoptic nucleus neurosecretory cells.
  • To elucidate the specific ionic mechanisms underlying the shortening of action potential duration during postnatal development.

Main Methods:

  • Electrophysiological recordings of action potentials and voltage-gated currents in acutely dissociated neurosecretory cells.
  • Pharmacological manipulation using cadmium to assess calcium current contribution.

Related Experiment Videos

  • Mathematical modeling based on Hodgkin-Huxley equations to simulate action potential dynamics.

    • Main Results:

    • Action potential duration significantly decreased from 2.7 ms to 1.8 ms between postnatal weeks 1 and 3.
    • Increased conductance density of sustained potassium currents and a decreased contribution of calcium currents were observed.
    • Mathematical modeling confirmed that increased potassium current density reduces action potential duration and calcium influx.

    Conclusions:

    • The developmental shortening of action potential duration is primarily driven by an increase in sustained potassium currents.
    • This developmental process leads to a reduced participation of calcium currents in action potentials.
    • Consequently, there is a significant decrease in calcium entry into neurosecretory cells during each action potential as development progresses.