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Dyschromatosis

K Urabe1, Y Hori

  • 1Department of Dermatology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Seminars in Cutaneous Medicine and Surgery
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Dyschromatoses are skin disorders with hyperpigmented and hypopigmented macules. Two main types, DSH and DUH, are common in Japan, with distinct distributions and onset.

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Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Dyschromatoses are characterized by mixed hyperpigmented and hypopigmented macules.
  • Two primary forms, dyschromatosis symmetrica hereditaria (DSH) and dyschromatosis universalis hereditaria (DUH), are prevalent in Japan.

Purpose of the Study:

  • To review the characteristics of DSH and DUH.
  • To discuss the differential diagnosis of dyschromatoses.

Main Methods:

  • Literature review of dyschromatosis cases and descriptions.
  • Comparison of clinical features of DSH and DUH.

Main Results:

  • DSH presents with symmetrical macules on extremities, first described in 1929.
  • DUH features generalized macules appearing within the first month of life, described in 1933.

Conclusions:

  • DSH and DUH are distinct dyschromatoses, though their relationship requires further genetic investigation.
  • Differential diagnosis includes xeroderma pigmentosum, dyschromic amyloidosis, and chemical exposures.