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Personality disorder scores improve with effective pharmacotherapy of depression
1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110-1093, USA. Kevin_Black@npg.wustl.edu
Introduction:
We hypothesized that the probability of personality disorder ('PROB') predicted by the Temperament and Character Inventory ('TCI') would decline after successful pharmacotherapy of depression.
Methods:
We administered a computerized version of the TCI to 15 patients with DSM-III-R major depression, before and after treatment with serotonergic antidepressants.
Results:
PROB declined from 58.9% +/- 18.0% to 42.4% +/- 22.8% (P < 0.003), due to a significant increase in the Self-Directedness scale. This change in PROB correlated with improvement in self-rated severity of depression (P < 0.02).
Conclusion:
TCI prediction of personality disorder is susceptible to state effects of depression.