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Surgical management of aortic regurgitation associated with ventricular septal defect
Insights
Aortic commissural valvuloplasty effectively treats pediatric congenital aortic regurgitation (AR) with ventricular septal defect (VSD), showing low mortality and reoperation rates. Long-term follow-up demonstrates favorable event-free survival for this surgical intervention.
Area of Science:
- Cardiovascular Surgery
- Pediatric Cardiology
- Congenital Heart Defects
Background:
- Congenital aortic regurgitation (AR) in pediatric patients often coexists with ventricular septal defects (VSD).
- Surgical management of these combined conditions presents unique challenges.
Purpose of the Study:
- To review the surgical outcomes of aortic commissural valvuloplasty (AVP) for congenital AR with VSD in pediatric patients.
- To evaluate the long-term efficacy and safety of AVP in this specific patient population.
Main Methods:
- Retrospective review of 34 pediatric patients who underwent AVP for AR and VSD between 1979 and 1994.
- Angiographic assessment of AR severity (Sellers' classification) and VSD types (subpulmonary, perimembranous, mixed).
- Kaplan-Meier analysis for event-free survival rates.
Main Results:
- No operative or late deaths were observed.
- Mean follow-up was 11.3 years; 78% of patients maintained an AR grade below mild.
- Overall 5-year and 10-year event-free rates were 96.6% and 92.8%, respectively.
Conclusions:
- Aortic commissural valvuloplasty is a beneficial surgical option for pediatric patients with congenital AR and VSD.
- The procedure demonstrates low mortality and reoperation rates, with favorable long-term outcomes.
Abstract:
Surgical treatment for congenital aortic regurgitation (AR) with ventricular septal defect (VSD) in pediatric patients carried out between 1979 and 1994 was reviewed. Aortic commissural valvuloplasty (AVP) was performed on prolapsed cusps in 34 patients (mean age 6.3 +/- 3.3 years (range: 2 to 24 years) with AR and VSD. The preoperative grade of AR was 2.6 +/- 0.8 measured angiographically by Sellers' classification. Patients had greater than moderate AR in conjunction with subpulmonary (n = 16), perimembranous (n = 15) or mixed type VSD (n = 3). In total, 25 right coronary cusps (RCC), five non-coronary cusps (NCC) and one left coronary cusp were repaired. In two cases, both RCC and NCC were plicated. One case had bicuspid valve and both cusps were repaired. There were no operative or late deaths. Moreover, the AR grade of the 25 cases has been below mild during a mean of 11.3 years follow up, though seven cases (22%) have developed above moderate AR. The two cases with persistent AR required redo AVP, with one having aortic valve replacement eventually after redo surgery. The operative findings showed cusp perforation on the repair site, or cusp elongation. However, the overall event-free rate analyzed by the Kaplan-Meier method was sufficiently favorable, with 96.6 +/- 3.4% for 5 years and 92.8 +/- 4.9% for 10 years. We conclude that aortic valvuloplasty for aortic regurgitation and VSD in pediatric patients is beneficial, with low mortality and reoperation rates.