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Pathogenesis and management of bone lesions in multiple myeloma
R Bataille1, S C Manolagas, J R Berenson
1Institute of Biology, Nantes, France.
Hematology/Oncology Clinics of North America
|April 1, 1997
Abstract:
Osteolytic lesions are among the hallmarks of multiple myeloma (MM). On the other hand, they are rare in B cell malignancies other than MM. Data have shown a close relationship between myeloma cell growth factors and factors involved in the occurrence of bone lesions in MM. Biophosphonates, which are potent inhibitors of bone resorption to control MM-induced hypercalcemia, are of interest due to their ability to slow the progression of MM bone disease.