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Dental development in Apert syndrome

S Kaloust1, K Ishii, K Vargervik

  • 1Department of Growth and Development, University of California at San Francisco 94143-0442, USA.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|March 1, 1997
PubMed
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Children with Apert syndrome experience delayed dental development, with an average delay of nearly one year. This delay in tooth eruption increases as the child gets older.

Area of Science:

  • Craniofacial anomalies
  • Pediatric dentistry
  • Developmental biology

Background:

  • Apert syndrome is a rare genetic disorder characterized by craniosynostosis and syndactyly.
  • While extensively studied, the dental development in Apert syndrome patients remains underexplored.
  • Clinical observations suggest delayed permanent tooth eruption in children with Apert syndrome.

Purpose of the Study:

  • To evaluate the dental development in individuals with Apert syndrome.
  • To compare the dental development of Apert syndrome patients with that of unaffected children.
  • To identify potential correlations between age and dental developmental delay in Apert syndrome.

Main Methods:

  • Retrospective analysis of panoramic radiographs from 36 Apert syndrome patients (ages 4.1-15.8 years) from four craniofacial centers.

Related Experiment Videos

  • Dental development assessed using Demirjian and Goldstein's eight-stage scale for seven left mandibular permanent teeth.
  • Dental maturity scores converted to dental age and compared with chronological age to determine developmental delay.

    • Main Results:

    • Thirty-one out of 36 Apert syndrome patients exhibited a dental age younger than their chronological age.
    • A mean developmental dental delay of 0.96 years was observed compared to a normal sample (p < .001).
    • A positive correlation was found between increased chronological age and a greater delay in dental development (p < .05).

    Conclusions:

    • The study confirms a significant mean developmental delay in the dentition of Apert syndrome patients.
    • A trend of increasing dental developmental delay with advancing age was observed.
    • These findings parallel the general growth patterns in Apert syndrome, indicating progressive delays as children age.