[An evaluation of the immunotropic and hemopoietic effects of hyperbaric oxygenation as an experimental pathological...

Apoptosis, programmed cell death, being a physiological process is manifested by degenerative changes of the cell structures. Augmentation of apoptosis or distributed receptor-signal interaction of the cells may be caused by the toxic products of radiolysis and cancerogenesis. Hyperbaric oxygenation (HBO) was used as a model resembling apoptosis. The parameter of the humoral immune response to different HBO regimens and correction of immunodepression by a carotene-tocopherol complex (CTC) were compared. The next stage in the study of the CTC antioxidant effect in gamma-radiation was determination of the extent of endogenous colony formation under the influence of different HBO regimens. A moderate immunodepressive effect of HBO was noted. Combination of CTC and HBO in small regimens induced a moderate immunostimulating and hemopoietic response. The suggested pathological model may be used in study of antioxidants. CTC showed hemopoietic and immunocorrective action.