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[Cholestasis associated with ticlopidine]
A Díaz Fuenzalida1, H Valdés Socín, O Laudano
1Departamento de Medicina Interna, Hospital de Clinicas José de San Martín, Universidad de Buenos Aires, Argentina.
Gastroenterologia Y Hepatologia
|March 1, 1997
Summary
Ticlopidine, a medication for peripheral arteriopathy, can cause cholestasis, a rare adverse effect. Discontinuation of the drug led to the resolution of cholestasis symptoms and normalization of liver function tests.
Area of Science:
- Hepatology
- Clinical Pharmacology
- Internal Medicine
Background:
- Cholestasis is a condition characterized by impaired bile flow.
- Ticlopidine is an antiplatelet medication used to treat peripheral arteriopathy.
- Adverse drug reactions can manifest as liver injury, including cholestasis.
Observation:
- A 56-year-old male presented with jaundice, choluria, and itching.
- Symptoms persisted for one month despite ticlopidine discontinuation one week prior to admission.
- Liver biopsy revealed acinar cholestasis and portal inflammation.
Findings:
- The patient's cholestasis was attributed to hypersensitivity to ticlopidine.
- Discontinuation of ticlopidine led to a decrease in cholestasis parameters.
- Clinical and biochemical parameters normalized within 4 months post-discontinuation.
Implications:
- This case underscores the importance of considering drug-induced cholestasis in patients presenting with these symptoms.
- Early recognition and withdrawal of the offending agent, ticlopidine, are crucial for favorable outcomes.
- Physicians should remain vigilant for rare adverse effects of commonly prescribed medications.