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Pathogenesis of endometriosis
1Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut, USA.
Obstetrics and Gynecology Clinics of North America
|June 1, 1997
Abstract:
This article reviews the pathogenesis of endometriosis, which involves retrograde dissemination of endometrium and/or development in situ by metaplasia, and there is evidence suggesting that genetic and hormonal factors may play a role. There is also substantial evidence that immunologic factors, namely peritoneal macrophages, T cells, natural killer cells, and soluble products secreted by these cells, are involved in the pathogenesis of endometriosis.