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Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial
N McDermott1, Y Suliman, C B Walsh
1Royal College of Surgeons in Ireland, Dublin, Republic of Ireland.
British Journal of Obstetrics and Gynaecology
|May 1, 1997
Abstract:
We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN (n = 16) and also from normal cervix (n = 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect.