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[Neutropenia in HIV infection]
1Hospital General Penitenciario, Madrid.
Unlabelled:
The infection by human immunodeficiency virus (HIV) are commonly associated with haematologic abnormalities (anemia, leucopenia and thrombocytopenia). We review the neutropenia. In patients infected with HIV neutropenia is seen in the 8-50% of them, and also have abnormalities in the neutrophil function.
Etiology:
Direct injury of HIV on de bone marrow, anti-neutrophil antibodies, drugs, opportunistic infections of bone marrow, vitamin B12 and folate deficiency, radiations therapy, and hemophagocytic syndrome.
Consequences:
These patients have a increased risk of infections, since the neutrophils play an important role in the defense against bacterial and certain fungal infections.
Treatment:
It must to treat the causes. When it is not possible, Colony-Stimulating Factor can be use to stimulate the bone marrow granulopoiesis.