Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmunity to the thyroid stimulating hormone receptor

S A Patibandla1, B S Prabhakar

  • 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555, USA.

Advances in Neuroimmunology
|January 1, 1996
PubMed
Summary

Autoimmune thyroid diseases, like Graves

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Regulatory T cells in multiple sclerosis and myasthenia gravis.

Journal of neuroinflammation·2017
Same author

MADD/DENN splice variant of the IG20 gene is necessary and sufficient for cancer cell survival.

Oncogene·2006
Same author

Correlation of disease evolution with progressive inflammatory cell activation and migration in the IL-4 transgenic mouse model of atopic dermatitis.

Clinical and experimental immunology·2005
Same author

Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model.

Clinical and experimental immunology·2004
Same author

Relevance of differential immunogenicity of human and mouse recombinant desmoglein-3 for the induction of acantholytic autoantibodies in mice.

Clinical and experimental immunology·2003
Same author

Targeted delivery of anti-CTLA-4 antibody downregulates T cell function in vitro and in vivo.

Clinical immunology (Orlando, Fla.)·2001

Area of Science:

  • Endocrinology
  • Immunology
  • Autoimmune diseases

Background:

  • Thyroid disorders are common endocrine diseases, often autoimmune.
  • Autoimmune thyroid diseases include Hashimoto's thyroiditis and Graves' disease.
  • These conditions involve immune responses to thyroid antigens like thyroglobulin and thyrotropin receptor.

Purpose of the Study:

  • To review thyroid diseases mediated by autoimmune responses to the thyrotropin receptor.
  • To highlight the role of specific antigen-directed autoimmunity in pathogenesis.

Main Methods:

  • Literature review focusing on autoimmune responses to the thyrotropin receptor.
  • Analysis of immune mechanisms in Graves' disease.

Main Results:

  • Graves' disease is primarily mediated by antibodies targeting the thyrotropin receptor.
  • Specific autoimmune responses to antigens play a key role in disease development.

Conclusions:

  • Autoimmunity to the thyrotropin receptor is a central mechanism in Graves' disease.
  • Understanding these specific autoimmune responses is crucial for thyroid disease research.

Related Experiment Videos