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Related Experiment Videos

Inducible receptors

L F Donaldson1, M R Hanley, A C Villablanca

  • 1Department of Cell Physiology and Pharmacology, University of Leicester, UK.

Trends in Pharmacological Sciences
|May 1, 1997
PubMed
Summary
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Tissue de novo receptor expression, involving various receptor types, occurs in disease and physiological processes. This finding offers new therapeutic targets and explains unexpected drug side effects.

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Physiology

Background:

  • Receptor expression is typically viewed as an all-or-none phenomenon within a tissue.
  • Regulation of receptor function occurs at multiple levels, including transcriptional and post-translational modifications.

Purpose of the Study:

  • To discuss circumstances of de novo receptor expression.
  • To explore potential mechanisms driving receptor induction.
  • To examine the pharmacological implications of induced receptors.

Main Methods:

  • Review of literature on de novo receptor expression.
  • Analysis of pathological and physiological processes associated with receptor induction.
  • Discussion of receptor classes affected, including G protein-coupled receptors and receptor tyrosine kinases.

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Main Results:

  • De novo receptor expression is observed in various physiological (e.g., angiogenesis) and pathological (e.g., tissue injury) conditions.
  • Induced receptors span diverse classes, not limited to specific receptor types.
  • This phenomenon has significant implications for identifying novel therapeutic targets.

Conclusions:

  • De novo receptor expression challenges the traditional all-or-none view of receptor presence in tissues.
  • Understanding receptor induction mechanisms can reveal new therapeutic strategies.
  • This finding may elucidate unexpected side effects in current pharmacotherapy.