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[Thyroid function in patients with Yusho: 28 year follow-up study]

H Tsuji1, K Sato, J Shimono

  • 1Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Fukuoka Igaku Zasshi = Hukuoka Acta Medica
|May 1, 1997
PubMed
Summary

Polychlorinated biphenyls (PCBs) exposure in Yusho patients may elevate thyroid stimulating hormone (TSH) and is associated with thyroglobulin antibodies. However, PCB levels did not correlate with other thyroid hormone levels.

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Bioscience, biotechnology, and biochemistry·1995

Area of Science:

  • Environmental Medicine
  • Endocrinology
  • Toxicology

Context:

  • Yusho disease, caused by dioxin-like compounds, provides a unique model for studying chronic environmental toxicant exposure.
  • Polychlorinated biphenyls (PCBs) are persistent organic pollutants with known endocrine-disrupting potential.
  • Thyroid dysfunction is a recognized concern in populations exposed to environmental contaminants.

Purpose:

  • To investigate the chronic effects of polychlorinated biphenyl (PCB) exposure on thyroid function in Yusho patients.
  • To assess thyroid hormone levels and the prevalence of thyroidal autoantibodies in relation to blood PCB concentrations.
  • To determine potential correlations between PCB levels and indicators of thyroid dysfunction.

Summary:

  • Elevated thyroid stimulating hormone (TSH) was observed in 8.6% of Yusho patients, indicating latent hypothyroidism, but without significant changes in triiodothyronine (T3), thyroxine (T4), or free T4 levels.

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  • No significant correlations were found between blood PCB concentrations and TSH, T2, T4, or free T4 levels.
  • Thyroglobulin antibodies were more prevalent in Yusho patients with higher PCB concentrations (19.5% with >3.0 ppb) compared to those with lower concentrations (2.5% with <2.9 ppb), suggesting an association.

    • Impact:

    • This study highlights a potential link between PCB exposure and the development of thyroglobulin antibodies in Yusho patients.
    • Findings suggest that while overt thyroid hormone disruption may not be common, subclinical thyroid alterations and autoimmune responses could be influenced by chronic PCB exposure.
    • The research contributes to understanding the long-term health consequences of environmental pollutants on endocrine systems, particularly thyroid function.