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A case of multiple nevoid hypertrichosis

S N Chang1, C E Hong, D K Kim

  • 1Department of Dermatology, Pochon CHA Medical School, Yonsei University College of Medicine, Seoul, Korea.

The Journal of Dermatology
|May 1, 1997
PubMed
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This study reports a rare case of nevoid hypertrichosis, a congenital disorder causing localized hair growth. The patient presented with multiple affected areas, showing decreased melanocytes in the skin.

Area of Science:

  • Dermatology
  • Genetics
  • Histopathology

Background:

  • Nevoid hypertrichosis is a rare congenital disorder characterized by localized terminal hair growth on normal-appearing skin.
  • It is typically present at birth or early childhood and is not associated with systemic abnormalities.
  • This condition presents a diagnostic challenge due to its rarity and varied presentation.

Observation:

  • A case of a 21-year-old male with multiple nevoid hypertrichosis lesions is presented.
  • Lesions included a chest area present since age 1 and additional areas on the left shoulder and upper arm that appeared at age 18.
  • The affected skin showed slight hypopigmentation and histological examination revealed terminal hair follicles with a marked decrease in HMB-45 positive melanocytes.

Findings:

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  • Histological examination confirmed the presence of terminal hair follicles in the affected skin.
  • A significant reduction in HMB-45 positive melanocytes was observed in the hypopigmented areas.
  • The absence of systemic abnormalities supports the diagnosis of isolated nevoid hypertrichosis.

    • Implications:

    • This case expands the understanding of nevoid hypertrichosis, particularly its potential for multiple and late-onset presentations.
    • The findings suggest a potential link between melanocyte reduction and the development of nevoid hypertrichosis.
    • Further research into the genetic and cellular mechanisms underlying this condition is warranted.