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Related Experiment Videos

Fluid turnover in renal cysts

L Jacobsson, B Lindqvist, G Michaelson

    Acta Medica Scandinavica
    |January 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Renal cyst fluid turnover is rapid, suggesting active transport by cyst wall cells, not glomeruli. This cellular function may be a target for pharmacotherapy in treating kidney cysts.

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    Area of Science:

    • Nephrology
    • Urology
    • Cell Biology

    Background:

    • Renal cysts, solitary or multiple, are common and can impair kidney function.
    • Understanding the dynamics of fluid within these cysts is crucial for developing effective treatments.

    Purpose of the Study:

    • To quantify fluid turnover in renal cysts.
    • To investigate the relationship between fluid turnover, cyst volume, pressure, and biochemical composition.
    • To elucidate the mechanisms of fluid transport across the cyst wall.

    Main Methods:

    • Percutaneous cystic puncture in 40 patients (18 solitary, 22 multiple congenital renal cysts).
    • Intravenous injection of tritiated water to estimate fluid turnover.
    • Measurement of cyst fluid volume, pressure, potassium, and creatinine levels.

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    Main Results:

    • Rapid fluid turnover was observed in all renal cysts.
    • Tritium concentration in cyst fluid reached 73-88% of plasma levels within 2-5 hours.
    • Fluid turnover was faster in smaller cysts and potentially influenced by potassium and creatinine levels, but not cyst pressure.
    • Estimated turnover for a 10 ml cyst exceeds 100 ml/24 hours.

    Conclusions:

    • Renal cyst fluid dynamics indicate active transport by cyst wall cells, mimicking tubular function.
    • Fluid inflow and outflow likely involve active solute transport by cyst cells.
    • Cyst wall cells possess tubular cell-like functions, suggesting potential for pharmacotherapy targeting these cells.