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Progress in protein structure prediction

D T Jones1

  • 1Department of Biological Sciences, University of Warwick, Coventry, UK. jones@globin.bio.warwick.ac.uk

Current Opinion in Structural Biology
|June 1, 1997
PubMed
Summary
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Protein structure prediction tools must evolve from theoretical concepts to practical software for genome analysis. Currently, ab initio tertiary-structure prediction lags behind comparative modeling and threading in this crucial transition.

Area of Science:

  • Computational biology
  • Structural bioinformatics

Background:

  • Genome sequencing projects are generating vast numbers of unknown protein sequences.
  • Effective analysis of these sequences requires robust protein structure prediction methods.
  • Existing methods like comparative modeling and threading are transitioning to practical tools.

Purpose of the Study:

  • To highlight the critical need for ab initio tertiary-structure prediction methods to become practical software tools.
  • To assess the current state of transition for different protein structure prediction approaches.

Main Methods:

  • Review of the current status of protein structure prediction methodologies.
  • Analysis of the transition from computational 'gedankenexperiments' to practical software applications.

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Main Results:

  • Comparative modeling and threading methods are successfully transitioning into practical software.
  • There is limited evidence of a similar transition for ab initio tertiary-structure prediction.

Conclusions:

  • The practical application of ab initio tertiary-structure prediction is essential for analyzing large-scale genomic data.
  • Further development is needed to translate ab initio methods into widely usable software tools.