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In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound
M D Bednarski1, J W Lee, M R Callstrom
1Department of Radiology, Stanford University School of Medicine, CA 94305, USA.
Radiology
|July 1, 1997
Abstract:
Magnetic resonance (MR) images in rabbit muscle were used to select a target region for application of pulsed-focused ultrasound. Liposomes encapsulating gadopentetate dimeglumine, an MR-detectable model representing pharmaceutical agents, were then injected intravenously. Focal enhancement on T1-weighted images, representing gadolinium-liposome accumulation, occurred in the pulsed-focused-ultrasound focal zone. Therefore, MR-guided pulsed-focused ultrasound targeted the delivery of macromolecular pharmaceutical agents within tissues.