Automated fluoride ion determination. Determination of serum fluoride ion levels

A method is described, using standard continuous flow techniques, for the automated determination of serum fluoride ion concentration using a fluoride ion selective electrode. It is shown that the kinetics of the electrode response to changes in fluoride ion can be used for the accurate measurement of fluoride ion concentration in serum, and that equilibration of the electrode response is not a prerequisite for the measurement of fluoride ion. Recovery experiments are in the range 86.6-98.5%, in-batch precision is 1.0-6.1%, between-batch precision 5.5%, with carryover of -2.99%.