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A new uncoupling protein: a potential component of the human body weight regulation system
1Department of Nutritional Sciences, University of California, Berkeley 94720-3104, USA.
Nutrition Reviews
|May 1, 1997
Abstract:
A mitochondrial protein that uncouples the respiratory chain from oxidative phosphorylation and generates heat is found in brown adipose tissue (BAT) of rodents. Although humans have little BAT, a second uncoupling protein has been discovered that is widely distributed in human tissues. It is induced in mice by a high-fat diet and in mice with obese mutations, and may play a role in human body weight regulation.