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The application of meta-analysis in assessing racial differences in the effects of antihypertensive medication

P Messeri1, S Workman, C Saunders

  • 1Urban Health Institute, Harlem Hospital Center, New York, New York, USA.

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
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Antihypertensive Drugs: Direct Renin Inhibitors

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Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

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Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...