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Transforming growth factor alpha-immunoreactivity in neural tissues of the rat stomach
P Hoffmann1, J M Zeeh, J Lakshmanan
1Division of Gastroenterology, Harbor UCLA Medical Center, Torrance, CA 90509, USA.
Regulatory Peptides
|April 30, 1997
Abstract:
We report TGF alpha immunoreactivity in neurons of the myenteric plexus and in nerve fibers in the muscle and submucosal layers of the rat stomach. Association of TGF alpha staining nerve fibers to vessels and smooth muscle cells gives morphological evidence that EGF/TGF alpha's actions to increase mucosal blood flow and gastric motility may be mediated by TGF alpha derived from neural structures. These data suggest that TGF alpha plays a role in the neural control of the gastric function.