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Annexins in the secretory pathway
1Department of Physiology, University College London, UK.
Cellular and Molecular Life Sciences : CMLS
|June 1, 1997
Summary
Annexins are proteins involved in cellular secretion. Annexin II acts as a calcium sensor, while others like annexins I and VII mediate vesicle aggregation, suggesting roles in regulated exocytosis.
Area of Science:
- Cell Biology
- Molecular Biology
Background:
- Annexins are a family of calcium-dependent phospholipid-binding proteins.
- Their roles in cellular processes, particularly regulated exocytosis, are under investigation.
Purpose of the Study:
- To review the evidence supporting annexin involvement in the secretory pathway.
- To evaluate annexins as potential mediators and regulators of exocytosis.
Main Methods:
- Literature review of studies on annexin function in exocytosis.
- Analysis of annexin properties, including calcium sensitivity and vesicle interaction.
Main Results:
- Annexin II exhibits properties of a calcium sensor for membrane fusion.
- Annexins I and VII show strong vesicle-aggregating activity, suggesting roles as exocytotic mediators.
- Annexin VI may function as a negative regulator by inhibiting vesicle aggregation.
Conclusions:
- The annexin family plays significant roles in the regulation of exocytosis.
- Different annexins may have distinct functions, acting as either positive or negative regulators of the secretory pathway.