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Related Experiment Videos

Cerebral glucose utilization is reduced in second test session

J M Stapleton1, M J Morgan, X Liu

  • 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
|June 1, 1997
PubMed
Summary
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Anxiety levels significantly impact brain glucose metabolism in repeated positron emission tomography (PET) scans. Low-anxiety individuals showed decreased metabolism over time, unlike high-anxiety subjects, highlighting anxiety as a key factor in PET research.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Psychophysiology

Background:

  • Positron emission tomography (PET) is a neuroimaging technique used to measure brain metabolism.
  • Anxiety is a psychological state that can influence physiological processes, including brain activity.
  • Repeated PET sessions in human volunteers may be affected by psychological factors like anxiety.

Purpose of the Study:

  • To investigate the effect of trait anxiety levels on cerebral glucose utilization during repeated PET sessions.
  • To determine if anxiety influences changes in brain metabolism over time in PET studies.
  • To examine hemispheric differences in cerebral metabolism related to anxiety levels.

Main Methods:

  • Utilized [18F]fluorodeoxyglucose ([18F]FDG) PET to assess cerebral glucose metabolism in male human volunteers.

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  • Conducted two PET sessions for each participant.
  • Categorized participants into low-trait anxiety and high-trait anxiety groups based on pre-study assessments.

    • Main Results:

    • Cerebral glucose utilization was significantly higher in the first PET session compared to the second session.
    • This decrease in metabolism over sessions was primarily observed in low-trait anxiety subjects.
    • High-anxiety subjects exhibited similar cerebral metabolism across both PET sessions.
    • High-anxiety subjects demonstrated greater right/left cerebral metabolism ratios than low-anxiety subjects, especially in the second session.

    Conclusions:

    • Trait anxiety is a critical confounding variable in longitudinal PET studies assessing cerebral glucose metabolism.
    • The observed changes in glucose utilization over repeated sessions are dependent on an individual's anxiety level.
    • Future PET research employing multiple sessions should account for participants' anxiety levels to ensure accurate interpretation of metabolic data.