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[Acquired cytomegalovirus infection in infants. A case successfully treated with ganciclovir]
1Service de Pédiatrie, Hôpital de Mevki Asker Hastanesi, Diskapi, Ankara, Turquie.
Insights
Ganciclovir effectively treated cytomegalovirus (CMV) hepatitis in an infant acquired postnatally. This antiviral medication offers a safe and successful treatment option for infants with symptomatic acquired CMV infections.
Area of Science:
- Virology
- Pediatric Infectious Diseases
- Pharmacology
Background:
- Cytomegalovirus (CMV) infection can be severe, especially congenital cases.
- Postnatally acquired CMV infections, while less severe, can still lead to complications and warrant treatment.
- Hepatitis is a potential manifestation of CMV infection in infants.
Observation:
- A 2.5-year-old infant presented with hepatitis attributed to a postnatally acquired CMV infection.
- The infant received a course of intravenous ganciclovir, with dosage adjustments over two months.
- No adverse effects or toxicity were noted during the treatment period.
Findings:
- The infant recovered completely from CMV hepatitis without any sequelae.
- Intravenous ganciclovir demonstrated efficacy in treating symptomatic acquired CMV infection in this pediatric case.
- The treatment regimen was well-tolerated by the infant.
Implications:
- Ganciclovir is a viable therapeutic option for symptomatic, postnatally acquired CMV infections in infants.
- This case supports the use of ganciclovir beyond severe congenital CMV infections.
- Further research into ganciclovir's role in managing various presentations of acquired CMV in neonates and infants is warranted.
Background:
Congenital cytomegalovirus infection is a severe condition. When acquired after birth prognosis is less severe although sensorial sequelae and risks justify treatment.
Case Report:
A 2.5 year old infant with hepatitis due to cytomegalovirus infection acquired after birth was treated with intravenous ganciclovir (7.5 mg/kg b.i.d for 2 weeks then 10 mg/kg three times a week for 2 months. No side effect or toxicity was observed and the patient recovered without sequellae.
Discussion:
In our experience, in addition to severe and symptomatic congenital cytomegalovirus infections, ganciclovir can be used in the treatment of less severe symptomatic acquired cytomegalovirus in infants.