Pergolide to augment the effectiveness of antidepressants: clinical experience and a small double-blind study

To attempt to confirm a prior report that pergolide can augment the efficacy of antidepressants in refractory patients, pergolide was administered to 12 patients receiving antidepressants. Eight patients were involved in a placebo-controlled evaluation of pergolide; the others were prescribed pergolide clinically. Results showed no evidence of benefit, so the double-blind study has been discontinued.