Effect of 2-chloroethanol on hepatic microsomal enzymes in the rat

The effect of 2-chloroethanol on the activities of hepatic microsomal enzymes in the rat has been studied. A significant reduction in activities of drug-metabolizing enzymes (aminopyrine N-demethylase, coumarin 3-hydroxylase) and a marked decrease of glucose 6-phosphatase were seen in both sexes given dose levels of 20 mg/kg sc daily for 7 days. Inosine diphosphatase activity remained unaltered. In male rats given 3 or 10 mg/kg, a trend in the inhibition of drug metabolism was found. A single dose of 50 mg/kg caused no apparent change in the activities of the enzymes measured.