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Dietary restriction affects antioxidant levels in rat liver mitochondria during ageing
T Armeni1, M Tomasetti, S Svegliati Baroni
1Institute of Genetics and Biology, University of Ancona, Italy.
Molecular Aspects of Medicine
|January 1, 1997
Abstract:
Six experimental groups of young (7-month-old) and aged (24-32-month-old) rats, underwent different dietary manipulations (i.e. dietary restriction and/or a vitamin E-depleted diet), and their liver mitochondria were assayed for several antioxidants and peroxidation markers. Glutathione levels were affected both by age and dietary treatment. Coenzyme Q9 and C0Q10 showed the highest levels in the oldest rats where ageing, as well as other oxidative stresses, could induce ubiquinone biosynthesis.