Related Experiment Video
Updated: Aug 3, 2026
Establishing a Porcine Ex Vivo Cornea Model for Studying Drug Treatments against Bacterial Keratitis
Published on: May 12, 2020
Pythium insidiosum keratitis
Abstract:
A case of Pythium insidiosum keratitis is described. It is an unusual organism that is difficult to isolate. Cases in animals and humans have been reported from tropical and subtropical parts of the world but this is the first case from a temperate region and was acquired from a hot pool. Although resembling a fungus, it is insensitive to all antifungals and requires wide surgical excision for cure.
Insights
Pythium insidiosum keratitis is a rare infection. This case, acquired from a hot pool in a temperate region, highlights the organism
Area of Science:
- Ophthalmology
- Medical Mycology
- Infectious Diseases
Background:
- Pythium insidiosum is an oomycete, often mistaken for a fungus.
- It causes a rare but severe keratitis, typically in tropical/subtropical regions.
- Diagnosis can be challenging due to difficulties in isolation.
Observation:
- A unique case of Pythium insidiosum keratitis is presented.
- The infection was acquired from a hot pool environment.
- This represents the first reported case in a temperate climate zone.
Findings:
- Pythium insidiosum is resistant to all antifungal treatments.
- Surgical excision is the primary treatment modality.
- Early diagnosis and intervention are crucial for visual outcomes.
Implications:
- Expands the known geographical distribution of Pythium insidiosum infections.
- Highlights non-traditional sources of infection, like recreational water.
- Emphasizes the need for alternative diagnostic and therapeutic strategies beyond antifungals.
