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The Prostate Cancer Intervention Versus Observation Trial (PIVOT)
1Department of Medicine, Minneapolis VA Medical Center, Minnesota, USA.
Oncology (Williston Park, N.Y.)
|August 1, 1997
Summary
The Prostate Cancer Intervention Versus Observation Trial (PIVOT) compares surgery versus watchful waiting for localized prostate cancer. This study aims to determine the best treatment for improving length and quality of life.
Area of Science:
- Urology
- Oncology
- Clinical Trials
Background:
- Localized prostate cancer presents a treatment dilemma regarding optimal management.
- Radical prostatectomy and expectant management are common treatment options.
- Evidence is needed to guide therapeutic decisions for localized prostate cancer.
Purpose of the Study:
- To compare radical prostatectomy versus expectant management for localized prostate cancer.
- To evaluate the impact of treatment on length and quality of life.
- To determine the preferred therapy for clinically localized prostate cancer.
Main Methods:
- The Prostate Cancer Intervention Versus Observation Trial (PIVOT) is a randomized clinical trial.
- Enrollment includes over 1,000 men under 75 years old with localized prostate cancer.
- Primary endpoint is all-cause mortality; secondary endpoints include morbidity, mortality, health status, and cost-effectiveness.
Main Results:
- Over 400 men randomized within the first 3 years.
- Baseline characteristics of enrollees are representative of the target population.
- Early data suggest the trial's findings will be generalizable to men with localized prostate cancer in the U.S.
Conclusions:
- The PIVOT trial is crucial for establishing evidence-based recommendations for localized prostate cancer treatment.
- Results will inform clinical practice and patient decision-making regarding surgery versus observation.
- This study will clarify the optimal management strategy for localized prostate cancer.