Related Experiment Videos
Intranasal absorption of oxymorphone
1The DuPont Merck Pharmaceutical Company, Pharmaceutical R&D, Wilmington, DE 19880-0400, USA.
Journal of Pharmaceutical Sciences
|August 1, 1997
Summary
Nasal administration of oxymorphone hydrochloride offers efficient drug delivery. This study found 43% nasal bioavailability in rats, suggesting a viable alternative to injections.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Pharmacokinetics
Background:
- Oxymorphone hydrochloride is an effective analgesic.
- Parenteral administration of analgesics can be invasive.
- Nasal drug delivery offers a non-invasive alternative route.
Purpose of the Study:
- To determine the nasal bioavailability of oxymorphone hydrochloride.
- To evaluate the pharmacokinetic profile of nasally administered oxymorphone hydrochloride.
- To assess the potential of nasal delivery as an alternative to injections.
Main Methods:
- Surgical isolation of the nasal cavity in rats.
- Intranasal administration of oxymorphone solution.
- Intravenous administration of oxymorphone hydrochloride as a reference.
- High-performance liquid chromatography (HPLC) for plasma concentration analysis.
Main Results:
- Rapid nasal absorption of oxymorphone.
- Nasal bioavailability of oxymorphone hydrochloride was determined to be 43%.
- Similar elimination profiles were observed for both intravenous and nasal routes.
Conclusions:
- Oxymorphone hydrochloride exhibits favorable properties for nasal delivery.
- Efficient nasal absorption and bioavailability support its use as an alternative to injections.
- Nasal delivery of oxymorphone hydrochloride presents a promising non-invasive therapeutic option.