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On-line liquid chromatography coupled with high field NMR and mass spectrometry (LC-NMR-MS): a new technique for drug
K I Burton1, J R Everett, M J Newman
1Pfizer Central Research, Sandwich, Kent, UK.
Journal of Pharmaceutical and Biomedical Analysis
|August 1, 1997
Abstract:
High performance liquid chromatography has been coupled simultaneously to high field NMR and MS detectors, giving UV, NMR and mass spectra for each component in a mixture, after on-line separation. This powerful new tool for the structure elucidation of components in mixtures without isolation has been successfully applied to the analysis of the metabolites of paracetamol in human urine.